Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors.

Ageing research reviews - 1 Aug 2017

Huebbe Patricia, Rimbach Gerald

Abstract excerpt

Apolipoprotein E (APOE) is a member of the vertebrate protein family of exchangeable apolipoproteins that is characterized by amphipathic α-helices encoded by multiple nucleotide tandem repeats. Its equivalent in flying insects - apolipophorin-III - shares structural and functional commonalities with APOE, suggesting the possibility of an evolutionary relationship between the proteins. In contrast to all other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Apolipoprotein E4
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Multigene Family

Share to Phylogeny

Share to Protein Isoforms

Source

Identifiers

PMID: 28647612
DOI: 10.1016/j.arr.2017.06.002

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors.PMID 28647612Read ↗

Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical FeaturesSemantic proximity Read ↗

Apolipoprotein E: far more than a lipid transport protein.Semantic proximity Read ↗

APOE Alleles and Diet in Brain Aging and Alzheimer’s DiseaseSemantic proximity Read ↗

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDSSemantic proximity Read ↗

ApoE genotype: from geographic distribution to function and responsiveness to dietary factors.Semantic proximity Read ↗

Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?Semantic proximity Read ↗

The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relations.Semantic proximity Read ↗

Apolipoprotein ESemantic proximity Read ↗

Apolipoprotein E4: an allele associated with many diseases.Semantic proximity Read ↗

The genetics of the human APOE polymorphism.Semantic proximity Read ↗

Beyond the CNS: The many peripheral roles of APOE.Semantic proximity Read ↗

Gain and loss events in the evolution of the apolipoprotein family in vertebrataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.