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Article

Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4.

Biochemistry - 28 Dec 2010

Nguyen David, Dhanasekaran Padmaja, Nickel Margaret, Nakatani Ryosuke, Saito Hiroyuki, Phillips Michael C, Lund-Katz Sissel

Abstract excerpt

Human apolipoprotein (apo) E4 binds preferentially to very low-density lipoproteins (VLDLs), whereas apoE3 binds preferentially to high-density lipoproteins (HDLs), resulting in different plasma cholesterol levels for the two isoforms. To understand the molecular basis for this effect, we engineered the isolated apoE N-terminal domain (residues 1-191) and C-terminal domain (residues 192-299) together with a...

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Identifiers

PMID: 21114327
DOI: 10.1021/bi1017655
PMCID: PMC3025481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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