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Article

The RGS14 GoLoco domain discriminates among Galphai isoforms.

The Journal of biological chemistry - 5 Nov 2004

Mittal Vivek, Linder Maurine E

Abstract excerpt

Regulators of G protein signaling (RGS) modulate G protein activity by functioning as GTPase-activating proteins (GAPs) for alpha-subunits of heterotrimeric G proteins. RGS14 regulates G protein nucleotide exchange and hydrolysis by acting as a GAP through its RGS domain and as a guanine nucleotide dissociation inhibitor (GDI) through its GoLoco motif. RGS14 exerts GDI activity on Galphai1, but not Galphao....

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Share to Amino Acid Motifs
Share to GTP-Binding Protein alpha Subunits, Gi-Go
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Guanosine 5'-O-(3-Thiotriphosphate)

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Source

Identifiers

PMID: 15337739
DOI: 10.1074/jbc.M407409200

Genes

RGS14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The RGS14 GoLoco domain discriminates among Galphai isoforms.PMID 15337739Read ↗

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