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Article

Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays.

The Journal of biological chemistry - 5 Sept 2014

Beautrait Alexandre, Michalski Kevin R, Lopez Thomas S, Mannix Katelynn M, McDonald Devin J, Cutter Amber R, Medina Christopher B, Hebert Aaron M, Francis Charnelle J, Bouvier Michel, Tesmer John J G, Sterne-Marr Rachel

Abstract excerpt

G protein-coupled receptor kinases (GRKs) phosphorylate agonist-occupied receptors initiating the processes of desensitization and β-arrestin-dependent signaling. Interaction of GRKs with activated receptors serves to stimulate their kinase activity. The extreme N-terminal helix (αN), the kinase small lobe, and the active site tether (AST) of the AGC kinase domain have previously been implicated in mediating the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25049229
DOI: 10.1074/jbc.M114.593178
PMCID: PMC4155688

Genes

GRK2
GRK1
GRK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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