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Article

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

Science (New York, N.Y.) - 9 Dec 2005

Tesmer Valerie M, Kawano Takeharu, Shankaranarayanan Aruna, Kozasa Tohru, Tesmer John J G

Abstract excerpt

G protein-coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G protein-coupled receptor signaling by phosphorylating activated heptahelical receptors and by sequestering heterotrimeric G proteins. We report the atomic structure of GRK2 in complex with Galphaq and Gbetagamma, in which the activated Galpha subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from...

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Share to Crystallography, X-Ray
Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Source

Identifiers

PMID: 16339447
DOI: 10.1126/science.1118890

Genes

GRK2
RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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