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Article

Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.

The Journal of cell biology - 11 Oct 2004

Koli Katri, Wempe Frank, Sterner-Kock Anja, Kantola Anna, Komor Martina, Hofmann Wolf-K, von Melchner Harald, Keski-Oja Jorma

Abstract excerpt

Disruption of latent TGF-beta binding protein (LTBP)-4 expression in the mouse leads to abnormal lung development and colorectal cancer. Lung fibroblasts from these mice produced decreased amounts of active TGF-beta, whereas secretion of latent TGF-beta was significantly increased. Expression and secretion of TGF-beta2 and -beta3 increased considerably. These results suggested that TGF-beta activation but not...

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Identifiers

PMID: 15466481
DOI: 10.1083/jcb.200403067
PMCID: PMC2172518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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