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Article

Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability.

Biochimica et biophysica acta - 1 Jan 2008

Drews Falko, Knöbel Sebastian, Moser Markus, Muhlack Kai G, Mohren Simone, Stoll Christian, Bosio Andreas, Gressner Axel M, Weiskirchen Ralf

Abstract excerpt

Latent transforming growth factor-beta binding proteins are a family of extracellular matrix proteins comprising four isoforms (LTBP-1, -2, -3, -4) with different structures, tissue expression patterns and affinity for TGF-beta. So far, respective knockout models have highlighted some essential functions for LTBP-2, LTBP-3 and LTBP-4, while the physiological significance of LTBP-1 is only superficially known....

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Identifiers

PMID: 17950478
DOI: 10.1016/j.bbamcr.2007.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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