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Article

Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice.

The Journal of clinical investigation - 1 Dec 2009

Heydemann Ahlke, Ceco Ermelinda, Lim Jackie E, Hadhazy Michele, Ryder Pearl, Moran Jennifer L, Beier David R, Palmer Abraham A, McNally Elizabeth M

Abstract excerpt

Most single-gene diseases, including muscular dystrophy, display a nonuniform phenotype. Phenotypic variability arises, in part, due to the presence of genetic modifiers that enhance or suppress the disease process. We employed an unbiased mapping approach to search for genes that modify muscular dystrophy in mice. In a genome-wide scan, we identified a single strong locus on chromosome 7 that influenced two...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19884661
DOI: 10.1172/JCI39845
PMCID: PMC2786802

Genes

LTBP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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