Article
Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.
The Journal of clinical investigation - 1 Mar 2012
Iwata Jun-ichi, Hacia Joseph G, Suzuki Akiko, Sanchez-Lara Pedro A, Urata Mark, Chai Yang
Abstract excerpt
Patients with mutations in either TGF-β receptor type I (TGFBR1) or TGF-β receptor type II (TGFBR2), such as those with Loeys-Dietz syndrome, have craniofacial defects and signs of elevated TGF-β signaling. Similarly, mutations in TGF-β receptor gene family members cause craniofacial deformities, such as cleft palate, in mice. However, it is unknown whether TGF-β ligands are able to elicit signals in Tgfbr2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.