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Article

Latent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability.

Human molecular genetics - 15 Jul 2015

Su Chi-Ting, Huang Jenq-Wen, Chiang Chih-Kang, Lawrence Elizabeth C, Levine Kara L, Dabovic Branka, Jung Christine, Davis Elaine C, Madan-Khetarpal Suneeta, Urban Zsolt

Abstract excerpt

Mutations in the gene for the latent transforming growth factor beta binding protein 4 (LTBP4) cause autosomal recessive cutis laxa type 1C. To understand the molecular disease mechanisms of this disease, we investigated the impact of LTBP4 loss on transforming growth factor beta (TGFβ) signaling. Despite elevated extracellular TGFβ activity, downstream signaling molecules of the TGFβ pathway, including pSMAD2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25882708
DOI: 10.1093/hmg/ddv139
PMCID: PMC4476448

Genes

LTBP4
TGFBR1
TGFBR2
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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