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Article

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis

10 Jul 2016

Abstract excerpt

Progressive tissue fibrosis is a major cause of the morbidity and mortality associated with repeated epithelial injuries and accumulation of myofibroblasts. Successful treatment options are limited by an incomplete understanding of the molecular mechanisms that regulate myofibroblast accumulation. Here, we employed in vivo lineage tracing and real-time gene expression transgenic reporting methods to analyze the...

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PMID: 27400124
DOI: 10.1172/jci85328

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