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Article

BMP3b is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts

21 Jun 2022

Abstract excerpt

Abstract Fibroblasts play a central role in the lung fibrotic process. Our recent study identified a novel subpopulation of lung fibroblasts expressing meflin (mesenchymal stromal cell- and fibroblast-expressing Linx paralogue), antifibrotic properties of which were confirmed by murine lung fibrosis model. Meflin-expressing fibroblasts were resistant to fibrogenesis induced by TGF-β (transforming growth...

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PMID: 35728045
DOI: 10.1165/rcmb.2021-0484oc

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