Article
Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.
Genes & development - 1 Sept 2002
Sterner-Kock Anja, Thorey Irmgard S, Koli Katri, Wempe Frank, Otte Jürgen, Bangsow Thorsten, Kuhlmeier Katharina, Kirchner Thomas, Jin Shenchu, Keski-Oja Jorma, von Melchner Harald
Abstract excerpt
Transforming growth factor-betas (TGF-betas) are multifunctional growth factors that are secreted as inactive (latent) precursors in large protein complexes. These complexes include the latency-associated propeptide (LAP) and a latent transforming growth factor-beta binding protein (LTBP). Four isoforms of LTBPs (LTBP-1-LTBP-4) have been cloned and are believed to be structural components of connective tissue...
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