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Article

Different mechanisms of radiation-induced loss of heterozygosity in two human lymphoid cell lines from a single donor.

Cancer research - 1 Feb 2001

Wiese C, Gauny S S, Liu W C, Cherbonnel-Lasserre C L, Kronenberg A

Abstract excerpt

Allelic loss is an important mutational mechanism in human carcinogenesis. Loss of heterozygosity (LOH) at an autosomal locus is one outcome of the repair of DNA double-strand breaks (DSBs) and can occur by deletion or by mitotic recombination. We report that mitotic recombination between homologous chromosomes occurred in human lymphoid cells exposed to densely ionizing radiation. We used cells derived from the...

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PMID: 11221843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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