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Article

Mutagenic radioadaptation in a human lymphoblastoid cell line.

Mutation research - 1 Feb 2008

Yatagai Fumio, Umebayashi Yukihiro, Honma Masamitsu, Sugasawa Kaoru, Takayama Yuko, Hanaoka Fumio

Abstract excerpt

We investigated the mutagenic radioadaptive response of human lymphoblastoid TK6 cells by pretreating them with a low dose (5 cGy) of X-rays followed by a high (2 Gy) dose 6h later. Pretreatment reduced the 2-Gy-induced mutation frequency (MF) of the thymidine kinase (TK) gene (18.3 x 10(-6)) to 62% of the original level (11.4 x 10(-6)). A loss of heterozygosity (LOH) detection analysis applied to the isolated...

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Identifiers

PMID: 17919664
DOI: 10.1016/j.mrfmmm.2007.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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