Article
Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts.
Mutagenesis - 1 Jan 1995
Dobo K L, Giver C R, Eastmond D A, Rumbos H S, Grosovsky A J
Abstract excerpt
In order to investigate the influence of loss of heterozygosity (LOH) events on mutation rate, we studied two closely related human lymphoblastoid cell lines, AHH-1 (h2E1.v2) and MCL-5, which are heterozygous at the tk locus (chromosome 17q23-25). Although they have similar mutant fractions at th...
Topics
- Aminacrine
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Chromosomes, Human, Pair 17
- DNA, Satellite
- Frameshift Mutation
- Genotype
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Lymphocytes
- Molecular Sequence Data
- Mutagenesis
- Mutagens
- Mutation
- Nitrogen Mustard Compounds
- Polymorphism, Genetic
- Thymidine Kinase