A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants.

doi:10.1016/0027-5107(92)90113-g

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Article

A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants.

Mutation research - 1 May 1992

Amundson S A, Liber H L

Abstract excerpt

Previously we described the dose-response relationship for X-ray-induced mutation of the two homologous alleles of the thymidine kinase (tk) gene in a human lymphoblastoid cell line (Amundson and Liber, 1991). The two alleles were differentially mutable by X-rays, with one allele 6-10 times more...

Topics

Alleles
Cells, Cultured
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
Genetic Markers
Heterozygote
Humans
In Vitro Techniques
Mutagenesis
Polymorphism, Restriction Fragment Length
Thymidine Kinase

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