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Article

Polymorphisms in genes involved in the corticosteroid response and the outcome of childhood acute lymphoblastic leukemia.

American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2004

Fleury Isabelle, Primeau Melanie, Doreau Agnes, Costea Irina, Moghrabi Albert, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

BACKGROUND: Considerable variability in sensitivity to corticosteroids (CS) has been observed among individuals with regard to both the natural and synthetic compounds. The role of genetic polymorphisms in modulating CS function, and hence in disease susceptibility, has been extensively analyzed. Their impact on therapeutic response still remains to be explored. The role of cytochrome P450 (CYP) 3A4 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15462611
DOI: 10.2165/00129785-200404050-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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