Article
Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia.
Radiology and oncology - 11 Sept 2018
Gasic Vladimir, Zukic Branka, Stankovic Biljana, Janic Dragana, Dokmanovic Lidija, Lazic Jelena, Krstovski Nada, Dolzan Vita, Jazbec Janez, Pavlovic Sonja, Kotur Nikola
Abstract excerpt
Background Response to glucocorticoid (GC) monotherapy in the initial phase of remission induction treatment in childhood acute lymphoblastic leukemia (ALL) represents important biomarker of prognosis and outcome. We aimed to study variants in several pharmacogenes (NR3C1, GSTs and ABCB1) that could contribute to improvement of GC response through personalization of GC therapy. Methods Retrospective study...
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