Article
The glucocorticoid receptor gene polymorphism N363S predisposes to more severe toxic side effects during pediatric acute lymphoblastic leukemia (ALL) therapy.
International journal of hematology - 1 Feb 2013
Eipel O T, Németh K, Török D, Csordás K, Hegyi M, Ponyi A, Ferenczy A, Erdélyi D J, Csóka M, Kovács G T
Abstract excerpt
The survival rates in childhood acute lymphoid leukemia (ALL) have improved dramatically; however, patients still suffer from a variety of drug-related toxicities. Individualized therapy regimens promise the least toxic therapy regimen with the best hematologic outcome. Our aim was to investigate whether increased individual glucocorticoid sensitivity due to the N363S polymorphism of the glucocorticoid receptor...
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