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Article

Association Between NR3C1 Gene Polymorphisms and Toxicity Induced by Glucocorticoids Therapy in Saudi Children with Acute Lymphoblastic Leukemia

Asian Pacific journal of cancer prevention : APJCP - 26 May 2018

El-Fayoumi Refaat, Hagras Magda, Abozenadaha Adel, Bawazir Waleed, Shinawi Thoraia

Abstract excerpt

Background: Glucocorticoids (GCs) are key hormones used for the treatment of acute lymphoblastic leukemia (ALL) in children, but their cytotoxic effects are not well defined. The aim of this study was to evaluate the association between polymorphisms in NR3C1 encoding for protein involved in the GCs metabolism and its role in the development of ALL and the toxicity outcome, in terms of liver toxicity, glucose...

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Identifiers

PMID: 29802709
DOI: 10.22034/APJCP.2018.19.5.1415
PMCID: PMC6031821

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