Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bim Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia

2 Aug 2013

Abstract excerpt

PURPOSE: Corticosteroids induce apoptosis in the malignant lymphoid cells and are critical component of combination therapy for acute lymphoblastic leukemia (ALL). Several genome-wide microarray studies showed major implication of proapoptotic Bim in mediating corticosteroid-related resistance in leukemia cells. EXPERIMENTAL DESIGN: We investigated Bim gene polymorphisms and their association with childhood ALL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Cancer therapeutics and mechanisms
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23908358
DOI: 10.1158/1078-0432.ccr-13-1215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bim Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic LeukemiaPMID 23908358Read ↗

Influence of BCL2L11 polymorphism on osteonecrosis during treatment of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cellsSemantic proximity Read ↗

Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemiaSemantic proximity Read ↗

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibitionSemantic proximity Read ↗

Severe toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatment.Semantic proximity Read ↗

Research Resource: Transcriptional Response to Glucocorticoids in Childhood Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Polymorphisms in genes involved in the corticosteroid response and the outcome of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Some GCR Polymorphisms (N363S, ER22/23EK, and Bcl-1) May Influence Steroid-induced Toxicities and Survival Rates in Children With ALLSemantic proximity Read ↗

Association of B-Lineage Lymphoblastic Leukaemia Gene Polymorphisms with Poor Prognostic Features.Semantic proximity Read ↗

Inherited genetic variants associated with glucocorticoid sensitivity in leukaemia cells.Semantic proximity Read ↗

Genetic Determinants of Treatment-Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.