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Article

Genetic variations in the glucocorticoid receptor gene are not related to glucocorticoid resistance in childhood acute lymphoblastic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2005

Tissing Wim J E, Meijerink Jules P P, den Boer Monique L, Brinkhof Bas, van Rossum Elisabeth F C, van Wering Elisabeth R, Koper Jan W, Sonneveld Pieter, Pieters Rob

Abstract excerpt

UNLABELLED: Glucocorticoid sensitivity is an important prognostic factor in pediatric acute lymphoblastic leukemia (ALL). For its antileukemic effect, glucocorticoid binds the intracellular glucocorticoid receptor (GR) subsequently regulating transcription of downstream genes. We analyzed whether genetic variations within the GR gene are related to differences in the cellular response to glucocorticoids. METHODS:...

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Share to Cell Survival
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Glucocorticoids

Share to Polymorphism, Single-Stranded Conformational

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Prednisolone

Share to Receptors, Glucocorticoid

Source

Identifiers

PMID: 16115950
DOI: 10.1158/1078-0432.CCR-04-2097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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