Article
Evaluating the effect of 3 glucocorticoid receptor gene polymorphisms on risk of relapse in 100 Iranian children with acute lymphoblastic leukemia: a case-control study.
Clinical therapeutics - 1 Mar 2011
Namazi Soha, Zareifar Soheila, Monabati Ahmad, Ansari Shahla, Karimzadeh Iman
Abstract excerpt
BACKGROUND: Glucocorticoids are an important component of treatment for childhood acute lymphoblastic leukemia (ALL). To induce antileukemic effects, glucocorticoids have to bind their intracellular receptors. Little is known about probable mechanisms of glucocorticoid resistance in ALL. OBJECTIVE: The aim of this study was to evaluate the possible association between 3 prominent glucocorticoid receptor gene...
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