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Article

Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL).

Leukemia research - 1 Apr 2010

Labuda Malgorzata, Gahier Annabel, Gagné Vincent, Moghrabi Albert, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

Childhood acute lymphoblastic leukemia patients (n=310) were analyzed for four SNPs in the NR3C1 gene. Polymorphisms -627A/G, intron 2 +646C/G and 9bT/C were all associated with reduced event-free survival. Haplotypes composed of AGT alleles at these loci and tagged by the intron 2 +646G variant also associated with lower event-free survival (p=0.03). The progressive impact of this haplotype on outcome was seen...

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Source

Identifiers

PMID: 19758697
DOI: 10.1016/j.leukres.2009.08.007

Genes

AGT

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