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Article

Severe toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatment.

Scientific reports - 26 Nov 2024

Leitão Luciana Pereira Colares, Monte Natasha, Rodrigues Juliana Carla Gomes, de Freitas Lilian Marques, Ribeiro-Dos-Santos André Maurício, Ribeiro-Dos-Santos Ândrea, Santos Sidney, de Souza Sandro José, Fernandes Marianne Rodrigues, Dos Santos Ney Pereira Carneiro

Abstract excerpt

Corticosteroids, such as prednisone or dexamethasone, constitute integral components of antineoplastic regimens for Acute Lymphoblastic Leukemia (ALL) therapy, albeit accompanied by significant adverse effects. The multifactorial nature of interindividual variability in drug response, encompassing genetic polymorphisms, underscores the complexity of pharmacotherapy outcomes. However, pharmacogenetic...

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Identifiers

PMID: 39592679
DOI: 10.1038/s41598-024-80393-3
PMCID: PMC11599904

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