Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion.

doi:10.1038/356154a0

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Article

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion.

Nature - 12 Mar 1992

Kitamura D, Rajewsky K

Abstract excerpt

Burnet's clonal selection theory suggests that each B lymphocyte is committed to a single antibody specificity. This is achieved by a programme of somatic rearrangements of the gene segments encoding antibody variable (V) regions, in the course of B-cell development. Evidence from immunoglobulin-...

Topics

Alleles
Animals
B-Lymphocytes
Base Sequence
Bone Marrow Cells
DNA
Exons
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Immunoglobulin kappa-Chains
Immunoglobulin mu-Chains
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 1545868
DOI: 10.1038/356154a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1545868-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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