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Article

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion.

Nature - 12 Mar 1992

Kitamura D, Rajewsky K

Abstract excerpt

Burnet's clonal selection theory suggests that each B lymphocyte is committed to a single antibody specificity. This is achieved by a programme of somatic rearrangements of the gene segments encoding antibody variable (V) regions, in the course of B-cell development. Evidence from immunoglobulin-transgenic mice and immunoglobulin-gene-transfected transformed pre-B cells suggest that the membrane form of the...

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PMID: 1545868
DOI: 10.1038/356154a0

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Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion.PMID 1545868Read ↗

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