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Article

Extended duration of DH-JH rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion.

The Journal of experimental medicine - 19 Apr 1999

Chang Y, Bosma M J, Bosma G C

Abstract excerpt

Here we show that suppression of VH-DJH rearrangement in mice bearing a mu heavy (H) chain transgene (mu-tg mice) is associated with an extended period of DH-JH rearrangement, the first step of Immunoglobulin H chain gene rearrangement. Whereas DH-JH rearrangement is normally initiated and completed at the pro-B cell stage, in mu-tg mice it continues beyond this stage and occurs most frequently at the small...

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Identifiers

PMID: 10209046
DOI: 10.1084/jem.189.8.1295
PMCID: PMC2193035

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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