Article
Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression.
Immunity - 1 Feb 1998
ten Boekel E, Melchers F, Rolink A G
Abstract excerpt
Within the pools of muH chain-producing precursor and mature B cells from normal and lambda5-defective mice, the frequency of cells in which both H chain alleles were productively VHDJH rearranged was determined. An equally high percentage (2%-4%) of cells carrying two productively VHDJH-rearrang...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Bone Marrow
- Cell Lineage
- Flow Cytometry
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Hematopoietic Stem Cells
- Immunoglobulin Light Chains
- Immunoglobulin Light Chains, Surrogate
- Immunoglobulin lambda-Chains
- Immunoglobulin mu-Chains
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Models, Immunological