Article
B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1998
Pewzner-Jung Y, Friedmann D, Sonoda E, Jung S, Rajewsky K, Eilat D
Abstract excerpt
To study the relative contributions of clonal deletion, clonal anergy, and receptor editing to tolerance induction in autoreactive B cells and their dependence on B cell receptor affinity, we have constructed "knock in" mice in which germline encoded or somatically mutated, rearranged anti-DNA he...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Antigens, Viral
- Autoantigens
- Autoimmunity
- B-Lymphocytes
- Base Sequence
- Bone Marrow Cells
- Clonal Anergy
- Clonal Deletion
- DNA
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Targeting
- Genes, Immunoglobulin
- Hybridomas
- Immunization