Allelic exclusion of membrane but not secreted immunoglobulin in a mature B cell line.

doi:10.1002/eji.1830210110

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Article

Allelic exclusion of membrane but not secreted immunoglobulin in a mature B cell line.

European journal of immunology - 1 Jan 1991

Picarella D, Serunian L A, Rosenberg N

Abstract excerpt

Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived from murine bone marrow that expresses two H chain proteins, gamma 3 and gamma 2b. Proteins of...

Topics

Alleles
Amino Acid Sequence
Animals
B-Lymphocytes
Base Sequence
Blotting, Northern
Cell Line
Gene Expression Regulation
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Isotypes

In Vitro Techniques

Membrane Proteins

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Oligonucleotides

Source

Open in PubMed

Identifiers

PMID: 1991490
DOI: 10.1002/eji.1830210110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1991490-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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