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Article

The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci.

Seminars in immunology - 1 Oct 1999

Melchers F, ten Boekel E, Yamagami T, Andersson J, Rolink A

Abstract excerpt

Membrane-bound preBCR of wild-type mice, and probably also preBCR-like V(preB) muH chain complexes in lambda5-deficient mice, signal allelic exclusion so that < 0.1% of all preB-II cells and all subsequent B lineage cells express two muH chains on their surface. On the other hand a large number of muH chains which are originally generated at the transition of preB-I to preB-II cells cannot pair with surrogate L...

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Source

Identifiers

PMID: 10497085
DOI: 10.1006/smim.1999.0187

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci.PMID 10497085Read ↗

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Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells.Semantic proximity Read ↗

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Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.Semantic proximity Read ↗

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