Article
Control of the sizes and contents of precursor B cell repertoires in bone marrow.
Ciba Foundation symposium - 1 Jan 1997
Melchers F
Abstract excerpt
Ordered rearrangements of immunoglobulin (Ig) gene loci, first as DH to JH, then as VH to DHJH, and finally as VL to JL segment-specific recombinations occur 'in-frame' and 'out-of-frame'. 'In-frame' rearrangements lead to the expression of truncated DHJH-microC proteins and to microH chains. The...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Bone Marrow Cells
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Hematopoietic Stem Cells
- Homeodomain Proteins
- Humans
- Immunoglobulin lambda-Chains
- Immunoglobulin mu-Chains
- Mice
- Nuclear Proteins
- Proteins
- Receptors, Antigen, B-Cell