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Article

Control of the sizes and contents of precursor B cell repertoires in bone marrow.

Ciba Foundation symposium - 1 Jan 1997

Melchers F

Abstract excerpt

Ordered rearrangements of immunoglobulin (Ig) gene loci, first as DH to JH, then as VH to DHJH, and finally as VL to JL segment-specific recombinations occur 'in-frame' and 'out-of-frame'. 'In-frame' rearrangements lead to the expression of truncated DHJH-microC proteins and to microH chains. These H chain proteins have two major effects on precursor B cells. They suppress (as DJC mu proteins) or enhance (as full...

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Identifiers

PMID: 9107420
DOI: 10.1002/9780470515280.ch12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Control of the sizes and contents of precursor B cell repertoires in bone marrow.PMID 9107420Read ↗

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