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Article

Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.

Neurology - 28 Sept 2004

Tan N C K, Heron S E, Scheffer I E, Pelekanos J T, McMahon J M, Vears D F, Mulley J C, Berkovic S F

Abstract excerpt

Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC...

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Share to Anticonvulsants
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epilepsy, Temporal Lobe

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Source

Identifiers

PMID: 15452306
DOI: 10.1212/01.wnl.0000137051.33486.c7

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.PMID 15452306Read ↗

No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population.Semantic proximity Read ↗

The controversial association of ABCB1 polymorphisms in refractory epilepsy: an analysis of multiple SNPs in an Irish population.Semantic proximity Read ↗

Lack of association between ABCC2 gene variants and treatment response in epilepsy.Semantic proximity Read ↗

Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy.Semantic proximity Read ↗

Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy.Semantic proximity Read ↗

Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy.Semantic proximity Read ↗

Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis.Semantic proximity Read ↗

Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.Semantic proximity Read ↗

Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.Semantic proximity Read ↗

Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy.Semantic proximity Read ↗

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach.Semantic proximity Read ↗

The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.Semantic proximity Read ↗

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