Article
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.
The New England journal of medicine - 10 Apr 2003
Siddiqui Asra, Kerb Reinhold, Weale Michael E, Brinkmann Ulrich, Smith Alice, Goldstein David B, Wood Nicholas W, Sisodiya Sanjay M
Abstract excerpt
BACKGROUND: One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death and debilitating psychosocial consequences. Because this form is resistant to multiple antiepileptic drugs, the mode of resistance must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1 and P-glycoprotein...
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