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Article

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach.

Pharmacogenetics and genomics - 1 Mar 2007

Leschziner Guy D, Andrew Toby, Leach John Paul, Chadwick David, Coffey Alison J, Balding David J, Bentley David R, Pirmohamed Munir, Johnson Michael R

Abstract excerpt

P-glycoprotein, the product of the ABCB1 gene, is a proposed mechanism of pharmacoresistance in epilepsy. Previous attempts to correlate the ABCB1 C3435T SNP, or a three-SNP haplotype containing C3435T with epilepsy pharmacoresistance have produced discordant findings. We analysed these single nucleotide polymorphisms (SNPs), plus a more comprehensive set of tagging SNPs describing common variation in ABCB1 in a...

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Identifiers

PMID: 17460550
DOI: 10.1097/01.fpc.0000230408.23146.b1

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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