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Article

Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis.

Epilepsia - 1 Apr 2009

Bournissen Facundo Garcia, Moretti Myla E, Juurlink David N, Koren Gideon, Walker Mugabe, Finkelstein Yaron

Abstract excerpt

BACKGROUND: Approximately one-third of patients with epilepsy patients have recurrent seizures despite therapy. It has been suggested that therapeutic failure is associated with high expression of the multidrug efflux ABCB1 (MDR1) drug-transporter; specifically, that patients with the 3435CC genotype have higher efflux of anticonvulsants out of brain tissue, with correspondingly lower concentrations in the...

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Source

Identifiers

PMID: 19178561
DOI: 10.1111/j.1528-1167.2008.01858.x

Genes

ABCB1

Variants

Provenance

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Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis.PMID 19178561Read ↗

ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis.Semantic proximity Read ↗

ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based on 8,604 subjects.Semantic proximity Read ↗

Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis.Semantic proximity Read ↗

The ABCB1-C3435T polymorphism likely acts as a risk factor for resistance to antiepileptic drugs.Semantic proximity Read ↗

Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.Semantic proximity Read ↗

Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese.Semantic proximity Read ↗

The roles of variants in human multidrug resistance (MDR1) gene and their haplotypes on antiepileptic drugs response: a meta-analysis of 57 studies.Semantic proximity Read ↗

Association between ABCB1 C3435T polymorphism and antiepileptic drug resistance in epilepsy: An updated meta-analysis based on 62 studies.Semantic proximity Read ↗

Association of MDR1 gene C3435T polymorphism with childhood intractable epilepsy: a meta-analysis.Semantic proximity Read ↗

Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy.Semantic proximity Read ↗

Association analysis of intractable epilepsy with C3435T and G2677T/A ABCB1 gene polymorphisms in Iranian patients.Semantic proximity Read ↗

Polymorphism of ABCB1/MDR1 C3435T in children and adolescents with partial epilepsy is due to different criteria for drug resistance - preliminary results.Semantic proximity Read ↗

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