Article
The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.
The Journal of experimental medicine - 4 Oct 2004
Hagenbeek Thijs J, Naspetti Marianne, Malergue Fabrice, Garçon Fabien, Nunès Jacques A, Cleutjens Kitty B J M, Trapman Jan, Krimpenfort Paul, Spits Hergen
Abstract excerpt
The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases. We have explored the role of the phosphoinositol(3,4,5)P3-phosphatase PTEN in T cell development by analyzing mice with a T cell-specific deletion of PTEN. Pten(flox/flox)Lck-Cre mice developed thymic lymphomas, but before the onset of tumors, they showed...
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