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Article

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

The Journal of experimental medicine - 3 Mar 2003

Suzuki Akira, Kaisho Tsuneyasu, Ohishi Minako, Tsukio-Yamaguchi Manae, Tsubata Takeshi, Koni Pandelakis A, Sasaki Takehiko, Mak Tak Wah, Nakano Toru

Abstract excerpt

Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell-specific mutation of Pten in mice (bPten(flox/flox)mice). bPten(flox/flox) mice showed elevated numbers of B1a cells and increased serum autoantibodies. Among B2 cells in bPten(flox/flox) sp...

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Identifiers

PMID: 12615906
DOI: 10.1084/jem.20021101
PMCID: PMC2193827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12615906-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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