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Article

Conditional deletion of Pten causes bronchiolar hyperplasia.

American journal of respiratory cell and molecular biology - 1 Mar 2008

Davé Vrushank, Wert Susan E, Tanner Tiffany, Thitoff Angela R, Loudy Dave E, Whitsett Jeffrey A

Abstract excerpt

Tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a lipid phosphatase that regulates multiple cellular processes including cell polarity, migration, proliferation, and carcinogenesis. In this work, we demonstrate that conditional deletion of Pten (Pten(Delta/Delta)) in the respiratory epithelial cells of the developing mouse lung caused epithelial cell proliferation and...

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Source

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Identifiers

PMID: 17921358
DOI: 10.1165/rcmb.2007-0182OC
PMCID: PMC2258453

Genes

PTEN
FOXJ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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