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Article

Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.

The Journal of clinical investigation - 1 Jul 2010

Liu Xiaohe, Karnell Jodi L, Yin Bu, Zhang Ruan, Zhang Jidong, Li Peiying, Choi Yongwon, Maltzman Jonathan S, Pear Warren S, Bassing Craig H, Turka Laurence A

Abstract excerpt

Mutations in the tumor-suppressor gene phosphatase and tensin homolog deleted on chromosome 10 (Pten) are associated with multiple cancers in humans, including T cell malignancies. Targeted deletion of Pten in T cells induces both a disseminated "mature phenotype" lymphoma and a lymphoproliferati...

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Topics

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Share to Lymphoma, T-Cell
Share to Autoimmune Lymphoproliferative Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Thymus Gland

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20516645
DOI: 10.1172/JCI42382
PMCID: PMC2898609

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20516645-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.PMID 20516645Read ↗

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.Semantic proximity Read ↗

The PTEN tumor suppressor gene and its role in lymphoma pathogenesis.Semantic proximity Read ↗

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.Semantic proximity Read ↗

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.Semantic proximity Read ↗

Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old StorySemantic proximity Read ↗

Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes.Semantic proximity Read ↗

Emerging role of PTEN loss in evasion of the immune response to tumours.Semantic proximity Read ↗

Portrait of PTEN: messages from mutant mice.Semantic proximity Read ↗

Dysregulated TCL1 promotes multiple classes of mature B cell lymphomaSemantic proximity Read ↗

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.Semantic proximity Read ↗

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.Semantic proximity Read ↗

Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma-GATA3 molecular subgroup.Semantic proximity Read ↗

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