Article
Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes.
Biochemical Society transactions - 1 Apr 2004
Suzuki A, Sasaki T, Mak T W, Nakano T
Abstract excerpt
To investigate the roles of the PTEN (phosphatase and tensin homologue deleted from chromosome 10)/PI3K (phosphoinositide 3-kinase) signalling pathway in vivo, we have generated a series of mutant mice with null or tissue-specific gene-targeted deletions of Pten. Here we present our investigations of Pten function in B cells and keratinocytes in mice. Mice with a B cell-specific mutation of Pten showed increased...
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