Article

Evidence that the protein phosphatase activity of PTEN contributes to embryonic development and tumour suppression in mice

2026-03-17

Abstract excerpt

PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumour suppressor, the function of which is impaired in many diverse cancers. It has phosphoinositide lipid phosphatase activity by which it suppresses activation of the oncogenic PI3K signalling network but in vitro also displays activity against protein substrates and is able to auto-dephosphorylate its Thr366 residue. Here we generate germl...

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Literature Corpus work: 3d7c6642-1a29-5543-aefb-58152a11d865
DOI: 10.64898/2026.03.14.711778

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