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Article

Variation in catechol-o-methyltransferase val158 met genotype associated with schizotypy but not cognition: a population study in 543 young men.

Biological psychiatry - 1 Oct 2004

Stefanis Nicholas C, Van Os Jim, Avramopoulos Dimitrios, Smyrnis Nikolaos, Evdokimidis Ioannis, Hantoumi Ioanna, Stefanis Costas N

Abstract excerpt

BACKGROUND: Increased catechol-O-methyltransferase activity associated with variation in catechol-O-methyltransferase valine158 methionine genotypes may result in reduced dopamine neurotransmission in the prefrontal cortex and thus contribute to the poor performance of frontally mediated cognitive tasks and the occurrence of associated negative symptoms observed in patients with schizophrenia; however, reported...

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Identifiers

PMID: 15450787
DOI: 10.1016/j.biopsych.2004.06.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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