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Article

Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction.

The American journal of clinical nutrition - 1 Oct 2004

Hustad Steinar, Nedrebø Bjørn G, Ueland Per Magne, Schneede Jørn, Vollset Stein Emil, Ulvik Arve, Lien Ernst A

Abstract excerpt

BACKGROUND: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy). Riboflavin status modifies the metabolic effect of the polymorphism, and thyroid hormones increase the synthesis of flavin cofactors. OBJECTIVE: The aim of the study was to investigate the...

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Share to Folic Acid
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homocysteine

Share to Hyperthyroidism

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

Share to Regression Analysis

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Source

Identifiers

PMID: 15447919
DOI: 10.1093/ajcn/80.4.1050

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction.PMID 15447919Read ↗

Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.Semantic proximity Read ↗

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Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.Semantic proximity Read ↗

Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample.Semantic proximity Read ↗

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The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene.Semantic proximity Read ↗

MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins?Semantic proximity Read ↗

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Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype.Semantic proximity Read ↗

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