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Article

Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.

The American journal of clinical nutrition - 1 Aug 2002

McNulty Helene, McKinley Michelle C, Wilson Barbara, McPartlin Joseph, Strain J J, Weir Donald G, Scott John M

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5) supplies the folate needed for the metabolism of homocysteine. A reduction in MTHFR activity, as occurs in the homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy). OBJECTIVE: In vitro studies suggest that the reduced activity of thermolabile...

Topics

Adult
Analysis of Variance
Female
Folic Acid
Genotype
Homocysteine
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Nutritional Requirements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nutritional Status

Oxidoreductases Acting on CH-NH Group Donors

Polymerase Chain Reaction

Riboflavin

Source

Identifiers

PMID: 12145019
DOI: 10.1093/ajcn/76.2.436

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.PMID 12145019Read ↗

Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype.Semantic proximity Read ↗

Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.Semantic proximity Read ↗

Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction.Semantic proximity Read ↗

Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism.Semantic proximity Read ↗

The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene.Semantic proximity Read ↗

Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations.Semantic proximity Read ↗

Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women.Semantic proximity Read ↗

Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.Semantic proximity Read ↗

Biological and clinical implications of the MTHFR C677T polymorphism.Semantic proximity Read ↗

Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype.Semantic proximity Read ↗

Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.Semantic proximity Read ↗

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