Article
MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins?
The Proceedings of the Nutrition Society - 1 Feb 2014
Reilly R, McNulty H, Pentieva K, Strain J J, Ward M
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is a critical folate-metabolising enzyme which requires riboflavin as its co-factor. A common polymorphism (677C→T) in the MTHFR gene results in reduced MTHFR activity in vivo which in turn leads to impaired folate metabolism and elevated homocysteine concentrations. Homozygosity for this polymorphism (TT genotype) is associated with an increased risk of a number of...
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