Article
Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism.
Clinical chemistry - 1 Aug 2000
Hustad S, Ueland P M, Vollset S E, Zhang Y, Bjørke-Monsen A L, Schneede J
Abstract excerpt
BACKGROUND: Plasma total homocysteine (tHcy) is a risk factor for cardiovascular disease. tHcy concentrations are partly determined by folate, cobalamin, and vitamin B(6) status, and methylenetetrahydrofolate reductase (MTHFR) and other flavoenzymes are important for the biotransformation of these vitamins. This motivates the investigation of the possible relationship between riboflavin status and tHcy. METHODS:...
Topics
- Adult
- Aged
- Amino Acid Substitution
- Cross-Sectional Studies
- Electrophoresis, Capillary
- Female
- Folic Acid
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Oxidoreductases Acting on CH-NH Group Donors