Article
Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample.
The American journal of clinical nutrition - 1 Mar 2003
de Bree Angelika, Verschuren W M Monique, Bjørke-Monsen Anne-Lise, van der Put Nathalie M J, Heil Sandra G, Trijbels Frans J M, Blom Henk J
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate and homocysteine metabolism. The common MTHFR 677C-->T polymorphism decreases the enzyme's activity. OBJECTIVE: The objective of the study was to assess the effect of the polymorphism on the relations among folate intake, plasma folate concentration, and total plasma homocysteine (tHcy) concentration. DESIGN: The design was a...
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