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Article

Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.

Circulation - 3 Jan 2006

McNulty Helene, Dowey Le Roy C, Strain J J, Dunne Adrian, Ward Mary, Molloy Anne M, McAnena Liadhan B, Hughes Joan P, Hannon-Fletcher Mary, Scott John M

Abstract excerpt

BACKGROUND: Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk of coronary heart disease by 11% to 16% and stroke by 19% to 24%. Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism have reduced MTHFR enzyme activity resulting from the inappropriate loss of the riboflavin cofactor, but it is unknown whether their typically high...

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Source

Identifiers

PMID: 16380544
DOI: 10.1161/CIRCULATIONAHA.105.580332

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.PMID 16380544Read ↗

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